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Efamol Evening Primrose Oil

Nutrivene Products : Essential Fatty Acids (DHA/GLA/Other Combination)

After extensive review and an evaluation by the Canadian Ministry of Health, Efamol Evening Primrose Oil is now officially approved as an effective treatment for atopic eczema!  
 
Efamol Evening Primrose Oil (EPO) is the most widely studied brand of EPO on the market. Evening Primrose Oil contains important GLA (gamma linolenic acid), an omega-6 fatty acid that acts as a precursor to prostaglandins. Prostaglandins help to improve immune function, circulation, and nerve function.  
 
For Healthy Skin  
People with healthy skin have normal blood levels of the essential fatty acid, linoleic acid and all the omega 6 fatty acids derived from it including gamm-linolenic acid (GLA).(1) These fatty acids help create an effective barrier in the skin to reduce water loss and maintain overall skin condition and integrity(2) including firmness, elasticity, strength and smoothness.(3,4) In addition, prostaglandins and other metabolites derived from these fatty acids modulate normal skin structure and function.(5) Supplementing the diet with Efamol Evening Primrose Oil ensures an intake of GLA that helps maintain healthy skin.(6)*  
 
For Mild Menstrual Related Symptoms  
Many women experience little or no discomfort, mild mood changes, bloating or breast tenderness associated with their menstrual cycle. These women also have normal levels of polyunsatured fatty acids (PUFAs) in their bodies(1,2) which may help control typical responses to circulating hormones.(3,4) Supplementing the diet with Efamol Evening Primrose Oil ensures an intake of PUFAs that support a normal, healthy attitude during premenstrual syndrome (PMS).(5,6,7)*  
 
For Nerve Function  
Fatty acids including gamma-linoleic acid (GLA) and other substances derived from it are important in nerve structure and function.(1) They are part of the myelin sheath, the protective insulation that surrounds all nerve fibers and enables them to transmit impulses correctly.(2) In addition, prostaglandins and other regulatory substances derived from these fatty acids help control blood flow around nerves ensuring vital supply of nutrients.(3,4) Nerve function can be assessed by measuring ability to detect skin temperature (hot and cold), muscle strength and reflexes, and how fast nerves can send messages.(5) Supplementing the diet with Efamol Evening Primrose Oil ensures an intake of GLA that helps maintain healthy nerve function.(6,7)*  
 
Efamol Evening Primrose Oil is available in a gelcap form and contains 180 softgels (500 mg each). Each gelcap contains 7 IU of Vitamin E, 350 mg of Linoleic Acid, and 58 mg of Gamma-Linolenic Acid. Other ingredients include gelatin and glycerin. Gelcaps may be pierced with a pin or cut open with scissors and the contents put into foods or liquids.  
 
Suggested daily intake: 2 capsules per day with food or drink. Taking this product for the first time: 6 capsules per day with food or drink for the initial 12 weeks. This higher initial daily intake is recommended to help optimize the body's store of important nutrients.  
 
 
*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  
 
Healthy Skin References  
(1)Manku MS, Horrobin DF, Morse NL, Wright S, Burton, JL. British Journal of Dermatology. 1984:110:643-648.  
(2)Wright S. Essential fatty acids and the skin. British Journal of Dermatology. 1991;125:503-515.  
(3)Muggli R. Efficacy of Efamol Evening Primrose Oil on the hydration, roughness, redness, TWEL and biochemical properties in non-irritated skin. International Journal Cosmetic Science. In press.  
(4)Nissen HP, Wehrmann W, Kroll U, Kreyser HW. Fat Sci Tech 1988;7:247-288.  
(5)Ziboh VA, Miller CC, Cho YH. Metabolism of polyunsatured fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metbolites. Amer J Clin. Nutr 2000;71:361S-6S. (6)Morse PF, Horrobin DF, Maku MS, Stewart JCM, Allen R, Littlewood S et al. Br J Dermatol 1989;121:75-90.  
 
Mild Menstrual Related Symptoms References  
(1)Brush MG, Watson SJ, Horrobin DF, Maka MS. Am J Obstet Gynecol 1984;150(4):363-3.  
(2)Horrobin DF, Manku MS, Brush M, Callender K, Preece PE, Mansel RE. Journal of Nutritional Medicine 1991;2:259-264.  
(3)Horrobin DF. Prostaglandins Leuko and Essent Fatty Acids. 1993;48:101-104.  
(4)Horrobin DF, Manku MS. Prostaglandins Leukotrienes and Essential Fatty Acids. 1989;37:255-261.  
(5)Puolakka J, Makaralinen L, Viinikka L, Ylikorkala O. The Journal of Reproductive Medicine 1985;Vol.30,No.3 March: 149-153.  
(6)Larsson B, Jonasson A, Fianu S. Current Therapeutic Research. 1989;Vol 46, No.1:58-63.  
(7)Ylikorkala O, Puolakka J, Makarainen L, Viinikka L. Prog Lipid Res 1986;25:433-435.  
 
Nerve Function References  
(1)Horrobin DF. Diabetes 1997;46(2):S90-S93.  
(2)Burnard Sl, McMurchie EJ, Leifert WR, Patten GS, Muggli R, Raederstorff D et al. J Diab Comp 1998;12:65-73  
(3)Cameron NE and Cotter MA. Diabetes 1997;46(2):S31-S37.  
(4)Head RJ, McLennan PL, Raederstorff D,Muggli R, Burnard SL, McMurchie EJ. Am J Clin Nutr 2000;71:386S-92S.  
(5)Jamal GA and Carmichael H. Diabetic Medicine 1990;7:319-323.  
(6)Dines KC, Cotter MA, Cameron NE. Prostaglandins Leukot Essent Fatty Acids.1996;55(3):159-165.  
(7)Keen H et al. Diabetes Care 1993;16:8-15.


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